Trometamol (Tris(Hydroxymethyl)aminomethane (Trometamol) high purity)

Chemical natures

White crystal or powder. soluble in ethanol and water, slightly soluble in ethyl acetate, benzene, insoluble in ether, carbon tetrachloride,copper,aluminum corrosion effects,irritant.

Applications

Tris, or tris(hydroxymethyl)aminomethane, or known during medical use as tromethamine or THAM, is an organic compound with the formula (HOCH2)3CNH2. It is extensively used in biochemistry and molecular biology as a component of buffer solutions such as in TAE and TBE buffers, especially for solutions of nucleic acids. It contains a primary amine and thus undergoes the reactions associated with typical amines, e.g. condensations with aldehydes. Tris also complexes with metal ions in solution. In medicine, tromethamine is occasionally used as a drug, given in intensive care for its properties as a buffer for the treatment of severe metabolic acidosis in specific circumstances. Some medications are formulated as the "tromethamine salt" including hemabate (carboprost as trometamol salt), and "ketorolac trometamol".

Physical form

White crystal or powder

Shelf life

According to our experience, the product can be stored for 12 months from the date of delivery if kept in tightly sealed containers, protected from light and heat and stored at temperatures between 5 - 30°C.

Typical properties

Boiling Point

357.0±37.0 °C at 760 mmHg

Melting Point

167-172 °C(lit.)

Flash Point

169.7±26.5 °C

Exact Mass

121.073891

PSA

86.71000

LogP

-1.38

Vapour Pressure

0.0±1.8 mmHg at 25°C

Index of Refraction

1.544

pka

8.1(at 25℃)

Water Solubility

550 g/L (25 ºC)

PH

10.5-12.0(4 m in water, 25 °C)